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The yin and yang of intestinal epithelial cells in controlling dendritic cell function.

TitleThe yin and yang of intestinal epithelial cells in controlling dendritic cell function.
Publication TypeJournal Article
Year of Publication2007
AuthorsIliev ID, Matteoli G, Rescigno M
JournalJ Exp Med
Volume204
Issue10
Pagination2253-7
Date Published2007 Oct 1
ISSN0022-1007
KeywordsAnimals, Dendritic Cells, Epithelial Cells, Humans, Inflammation, Intestines, Yin-Yang
Abstract

Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.

DOI10.1084/jem.20062535
Alternate JournalJ. Exp. Med.
PubMed ID17893197
PubMed Central IDPMC2118441